ea0021p168 | Diabetes and metabolism | SFEBES2009
Gathercole Laura
, Bujalska Iwona
, Morgan Stuart
, Hauton Dave
, Stewart Paul
, Tomlinson Jeremy
Patients with glucocorticoid excess develop a phenotype characterized by central obesity, however, the impact of glucocorticoids upon the processes that regulate lipid accumulation has not been fully explored. We hypothesize that intracellular generation of cortisol from cortisone by 11b-hydroxysteroid dehydrogenase type 1 (11bHSD1) is an important regulator of lipid metabolism.In adipocytes, acetyl-CoA carboxylase 1 and 2 (ACC1/2) convert acetyl-CoA to ...